Trends in Infective Endocarditis in California and New York State, 1998-2013
Nana Toyoda, MD, PhD, Joanna Chikwe, MD, Shinobu Itagaki, MD, MSc, AC Gelijns, MD, David H. Adams, MD, Natalia N. Egorova, PhD
IMPORTANCE:
Prophylaxis and treatment guidelines for infective endocarditis have changed substantially over the past decade. In the United States, few population-based studies have explored the contemporary epidemiology and outcomes of endocarditis.
OBJECTIVE:
To quantify trends in the incidence and etiologies of infective endocarditis in the United States.
DESIGN, SETTING, AND PARTICIPANTS:
Retrospective population epidemiology study of patients hospitalized with a first episode of endocarditis identified from mandatory state databases in California and New York State between January 1, 1998, and December 31, 2013.
EXPOSURE:
Infective endocarditis.
MAIN OUTCOMES AND MEASURES:
Outcomes were crude and standardized incidence of endocarditis and trends in patient characteristics and disease etiology. Trends in acquisition mode, organism, and mortality were analyzed.
CONCLUSIONS AND RELEVANCE:
In California and New York State, the overall standardized incidence of infective endocarditis was stable from 1998 through 2013, with changes in patient characteristics and etiology over this time.
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