Nana Toyoda, MD, PhD, Joanna Chikwe, MD, Shinobu Itagaki, MD, MSc, AC Gelijns, MD, David H. Adams, MD, Natalia N. Egorova, PhD
Prophylaxis and treatment guidelines for infective endocarditis have changed substantially over the past decade. In the United States, few population-based studies have explored the contemporary epidemiology and outcomes of endocarditis.
To quantify trends in the incidence and etiologies of infective endocarditis in the United States.
DESIGN, SETTING, AND PARTICIPANTS:
Retrospective population epidemiology study of patients hospitalized with a first episode of endocarditis identified from mandatory state databases in California and New York State between January 1, 1998, and December 31, 2013.
MAIN OUTCOMES AND MEASURES:
Outcomes were crude and standardized incidence of endocarditis and trends in patient characteristics and disease etiology. Trends in acquisition mode, organism, and mortality were analyzed.
CONCLUSIONS AND RELEVANCE:
In California and New York State, the overall standardized incidence of infective endocarditis was stable from 1998 through 2013, with changes in patient characteristics and etiology over this time.
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