Survival and long-term outcomes after mitral valve replacement in patients aged 18 to 50 years | Mitral Valve Repair Center Skip to main content

Samuel R. Schnittman, MD, David H. Adams, MD, Shinobu Itagaki, MD, Nana Toyoda, MD, Natalia N. Egorova, PhD, Joanna Chikwe, MD

OBJECTIVE:

To provide long-term data on survival and major morbidity after mitral valve replacement in patients aged 18 to 50 years.

METHODS:

Retrospective analysis of 2727 patients aged 18 to 50 years who underwent isolated mitral replacement in California and New York from 1997 to 2006. Median follow-up time was 12.4 years (maximum 15.0 years). The primary endpoint was mortality; secondary endopoints were stroke, major bleeding, and reoperation. Propensity matching yielded 373 patient pairs.

CONCLUSIONS:

The significant survival benefit associated with mechanical mitral valve replacement in adults ≤50 years may be due to the practice of implanting bioprostheses in sicker patients or those judged less likely to comply with long-term medication despite adjustment for baseline characteristics in propensity score matching.

Page Created: Jan. 03, 2018 Last Updated: Mar. 02, 2018

Publications

All Publications