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Farzan Filsoufi, Javier G. Castillo, Parwis B. Rahmanian, Corey Scurlock, Gregory Fischer, David H. Adams

November 01, 2006 | The Annals of Thoracic Surgery

Severe coagulopathy after cardiovascular surgery may lead to intractable bleeding and is associated with increased mortality and morbidity. Recent studies have suggested that recombinant activated factor VII (rFVIIa) may play a role in decreasing postoperative bleeding. ... This study suggests that rFVIIa is safe and efficacious in the management of refractory postcardiotomy bleeding. The use of rFVIIa is associated with reduced blood loss, rapid improvement of coagulation variables, and decreased need for blood products.

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