1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses
George M. Deeb, MD, ... David H. Adams, MD , Jeffrey J. Popma, MD
OBJECTIVES:
This study evaluated the safety and effectiveness of self-expanding transcatheter aortic valve replacement (TAVR) in patients with surgical valve failure (SVF).
BACKGROUND:
Self-expanding TAVR is superior to medical therapy for patients with severe native aortic valve stenosis at increased surgical risk.
METHODS:
The CoreValve U.S. Expanded Use Study was a prospective, nonrandomized study that enrolled 233 patients with symptomatic SVF who were deemed unsuitable for reoperation. Patients were treated with self-expanding TAVR and evaluated for 30-day and 1-yearoutcomes after the procedure. An independent core laboratory was used to evaluate serial echocardiograms for valve hemodynamics and aortic regurgitation.
CONCLUSIONS:
Self-expanding TAVR in patients with SVF at increased risk for surgery was associated with a low 1-year mortality and major stroke rate, significantly improved aortic valve hemodynamics, and low rates of moderate and no severe residual aortic regurgitation, with improved quality of life.
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Publications
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Failure to Rescue: A Quality Metric for Cardiac Surgery and Cardiovascular Critical Care
Caroline R Gross, David H Adams, Parth Patel, Robin Varghese -
In memoriam: Randall B. Griepp (1940-2022)
David H Adams, Dimosthenis Pandis -
Transcatheter Repair for Patients with Tricuspid Regurgitation
Paul Sorajja, MD, Brian Whisenant, MD, David H. Adams, MD, et al. -
Outcomes of Simultaneous Heart and Kidney Transplantation
Shinobu Itagaki, Nana Toyoda, Noah Moss, Donna Mancini, Natalia Egorova, Takahisa Mikami, Erick Sun, Yuki Bekki, Gregory Serrao, Anuradha Lala, Percy Boateng, David H Adams, Anelechi C Anyanwu